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徐正仁

助理教授,博士生导师

徐正仁 助理教授,博士生导师

国家第十四批“青年千人计划”入选者

 

地址:北京市海淀区学院路38号

邮编:100191

电话:010-82805253

E-mail:zhengrenxu@bjmu.edu.cn

 

研究兴趣

(1)新型酶催化反应研究

(2)生物催化及其在天然产物合成中的应用

 

教育背景

2001年-2005年,学士,药学,北京大学药学院

2005年-2007年,硕士,生药学,北京大学药学院(导师:屠鹏飞教授)

2007年-2011年,博士,化学生物学,北京大学药学院(导师:贾彦兴教授,张礼和教授)

工作经历

2011年10月-2014年9月,博士后,瑞士洛桑联邦理工大学(导师:祝介平教授)

2014年10月-2018年3月,博士后,美国斯克利普斯研究所(导师:沈奔教授)

2018年4月至今,助理教授,北京大学药学院醉红颜心水论坛

 

代表性论文

Xu, Z.*; Wang, Q.; Zhu, J.* Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids. Chem. Soc. Rev. 2018, 47 , ASAP

Pan, G.#; Xu, Z.#; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc. Natl. Acad. Sci. USA 2017, 114 , E11131-E11140. (#contribute equally)

Zhang, B.#; Xu, Z.#; Teng, Q.#; Pan, G.; Ma, M.; Shen, B. A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Ed. 2017, 56 , 7247-7251. (#contribute equally)

Xu, Z.#; Bao, X.#; Wang, Q.; Zhu, J. An enantioselective total synthesis of (-)-isoschizogamine. Angew. Chem. Int. Ed. 2015, 54 , 14937-14940. (Highlighted: in Synfacts 2016, 12 , 5.) (#contribute equally)

Tong, S.#; Xu, Z.#; Mamboury, M.; Wang, Q.; Zhu, J. Aqueous titanium trichloride-promoted reductive cyclization of o -nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine. Angew. Chem. Int. Ed. 2015, 54 , 11809-11812. (#contribute equally)

Xu, Z.; Wang, Q.; Zhu, J. Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomericanisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C. J. Am. Chem. Soc. 2015, 137 , 6712-6724.

Xu, Z.; Wang, Q.; Zhu, J. Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids. J. Am. Chem. Soc. 2013, 135 , 19127-19130. (Highlighted: in Synfacts 2014, 10 , 232.)

Xu, Z.; Wang, Q.; Zhu, J. Palladium-catalyzed decarboxylativevinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine. Angew. Chem. Int. Ed. 2013, 52 , 3272-3276. (Highlighted: in Synfacts 2013, 9 , 461.; in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2013/25November.shtmand http://www.organic-chemistry.org/Highlights/2014/10March.shtm.)

Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y. Total synthesis of (-)-indolactam V. Org. Biomol. Chem. 2011, 9 , 2512-2517.

Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y. Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied. J. Org. Chem. 2010, 75, 7626-7635.

Xu, Z.; Li, Q.; Zhang, L.; Jia, Y. Efficient total synthesis of (-)-cis-clavicipitic acid. J. Org. Chem. 2009, 74 , 6859-6862. (With a correction: J. Org. Chem. 2010, 75 , 6316; Highlighted in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2010/21June.shtm.)

Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y. Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o -chloroanilines and o -chloroaminopyridines with aldehydes. Synthesis 2008, 3981-3987.

Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F. Xylocosides A-G, phenolic glucosides from the stems of Xylosmacontroversum . Helv. Chim. Acta 2008, 91 , 1346-1354.

 Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F. Chemical constituentsfrom Xylosmacontroversum . J. Chin. Pharm. Sci. 2007, 16 , 218-222.